Coadministration is contraindicated during or within 14 days following the administration of MAOIs. Amphetamines should not be administered during or within 14 days following the use of most MAOIs or drugs with MAO-inhibiting activity selegiline increases effects of dextroamphetamine by pharmacodynamic synergism. Selegiline and dextroamphetamine both increase serotonin levels. Concomitant use could result in life-threatening serotonin syndrome. Coadministration is contraindicated during or within 14 days following the administration of MAOIs.Įither increases toxicity of the other by serotonin levels. Rasagiline increases effects of dextroamphetamine by pharmacodynamic synergism. Procarbazine increases effects of dextroamphetamine by pharmacodynamic synergism. ![]() Phenelzine increases effects of dextroamphetamine by pharmacodynamic synergism. Linezolid increases effects of dextroamphetamine by pharmacodynamic synergism. Isocarboxazid increases effects of dextroamphetamine by pharmacodynamic synergism. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives may cause false-negative imaging results. End stage renal disease (GFR 6-17 years: 5 mg once daily recommended not to exceed 20 mg once daily for children 6 to 12 years of age.12 years: 10 mg/day PO initially may increase by 10 mg/day qWeek not to exceed 60 mg given qDay or divided doses with intervals of 4-6 hr between doses Dosing Modifications Severe renal impairment. ![]() 6 years: 5 mg PO qDay or q12hr may increase by 5 mg qWeek not to exceed 40 mg qDay or divided q8hr use intervals of 4-6 hr between additional doses.ESRD (GFR Severe renal impairment (GFR 15 to ![]()
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